Published by Penerbit Goodwood, Jurnal Ilmu Medis Indonesia (JIMI) is a peer-reviewed scholarly journal that publishes articles in the field of medical sciences in Indonesia. JIMI welcomes researchers, academicians, as well as practitioners to submit well-written manuscripts discussing contempory and interesting medical issues aimed at mediating the development of Indonesian medical sciences through a quality scientific publication.
Published
2023-09-08
Articles
Peran Kadar Vitamin D Darah terhadap Derajat Keparahan Klinis Pasien Bell’s Palsy
Purpose: This study aims to determine the effect of blood vitamin D levels on clinical severity in patients with Bell's palsy.
Methodology/approach: The study was conducted with longitudinal observational analytic on patients with Bell’s palsy. Vitamin D levels in the form of 25-hydroxyvitamin D (25(OH)D were measured in each subject. The clinical severity was evaluated using the House-Brackmann grading.
Results/findings: A total of 20 patients (10 women, 10 men, mean age 48.8 ± 12, 97 years, range 22-72 years) were evaluated between March-July 2022. Vitamin D deficiency was present in 13 (65%) patients, insufficiency in 7 (35%) patients, and no normal blood vitamin D levels were found in patients with Bell’s palsy. Two (10%) patients with grade 3 Bell’s palsy, six (30%) grade 4 patients, and twelve (60%) grade 5 patients. Results showed higher clinical severity had lower vitamin D levels. Statistical analysis showed a significant difference with p value = 0.003.
Limitations: The research that discusses the dosage, method, and duration of vitamin D administration in patients with Bell's palsy still very limited.
Contribution: With further research, it can be proven vitamin D deficiency can be associated with Bell's palsy, so appropriate treatment and prevention can be given.
Mechanism of Alkaloids and Flavonoids in Bajakah (Uncaria nervosa Elmer) as Antidiabetic Agents
Purpose: Diabetes mellitus is a metabolic disease characterized by hyperglycemic resulting from defects of insulin secretion, insulin action, or both. One of the alternative treatments is bajakah which has antidiabetic activity. This study aims to further discuss the potential and mechanism of alkaloids and flavonoids in bajakah as antidiabetic agents.
Method: This study used the literature review method by searching research data on database and 5 articles included for the review.
Results: Alkaloids have antidiabetic activity through inhibition of AR, PTP1B, activating AMPK, inhibiting DDP-4 and AGEs, increasing glucose absorption, regenerating pancreatic beta cells, inhibiting and inducing GLUT-4, GSK-3, SREB-1, ACC, PPAR, and glucokinase mechanisms. Meanwhile, flavonoids have activity in pancreatic beta cell degradation, increasing insulin secretion and sensitivity, glucose homeostasis, glucose absorption through GLUT-2, inhibiting phosphodiesterase, inhibiting alpha glucosidase and alpha amylase enzymes, inhibiting apoptosis of pancreatic beta cells, encouraging proliferation, and lowering blood glucose.
Limitation: The limitation in this study is that it only used the literature review method which has weaknesses in the data studied. Researcher suggests that more rigorous methods be used in further studies to explore the effectiveness of bajakah in lowering blood glucose level and the need for a toxicity test of bajakah to determine therapeutic doses and lethal doses for the treatment of diabetes mellitus.
Contribution: The findings of this study are expected to be a reference in scientific development in the diabetes mellitus treatment using herbal plants. In addition, it is expected that it can increase further knowledge about the mechanism of bajakah as antidiabetic agents.
The Effect of Snail Mucus (Achatina fulica) on Wound Healing after Tooth Extraction: A Literature Review
Purpose: Tooth extraction is a frequently performed procedure within the field of dentistry, which results in a wound. The wound healing process can be enhanced by chemical and traditional medicines, one of which is snail mucus, which contains active compounds that play an important role in wound healing process. This study aims to further discuss regarding the effect of snail mucus on wound healing process after tooth extraction.
Methodology/approach: This literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through PubMed, ProQuest, and Google Scholar database.
Results/findings: Snail mucus contains active compounds, such as protein, glycosaminoglycans, metal elements, allantoin, sulfates, calcium, mytimacin-AF, collagen, elastin, glycolic acid, hyaluronic acid, glutathione and vitamins which have effectiveness in enhancing the wound healing process with different mechanisms for each compound, both hemostasis, inflammation, proliferation, and remodeling processes.
Limitation: The limitation of this literature review is the lack of high-quality research. Furthermore, the lack of information on the specific doses of snail mucus used and the duration of treatment are critical difficulties that should be addressed in future research to allow for more comprehensive meta-analysis. Additionally, it is required to conduct testing and comparative analysis of the composition of snail mucus across other species in order to ascertain the efficacy of snail mucus content in species other than Achatina fulica.
Contribution: The results of this literature review are expected to be a reference in scientific development of wound treatment using traditional medicine, particularly snail mucus. Additionally, it is expected to increase the understanding regarding the effect of snail mucus on wound healing after tooth extraction.
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