Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital

https://doi.org/10.35912/jimi.v4i2.4250
Published: Feb 18, 2025

Abstract:

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital.

Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study.

Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412).

Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts.

Limitations: The limited sample size and study duration suggest the need for further research.

Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.

Keywords:
1. Clinical Diagnosis
2. Laboratory Results
3. Neonatal Sepsis
Authors:
1 . Nailul Azizah
2 . Leni Ervina
3 . Khairunnisa Berawi
4 . Hendri Busman
5 . Bambang Irawann
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How to Cite
Azizah, N., Ervina, L., Berawi, K. ., Busman, H., & Irawan, B. (2025). Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital. Jurnal Ilmu Medis Indonesia, 4(2), 145–15. https://doi.org/10.35912/jimi.v4i2.4250
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Issue & Section
Vol. 4 No. 2 (2025): Maret
Articles
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  1. Agata, A. P. (2022). Pengelolaan Hipertensi Sebelum Kehamilan . Jurnal Medis Indonesia, 95-101.
  2. Celik, I. H. (2022). Diagnosis of neonatal sepsis. Paediatric Research, 337-350.
  3. Ervina, L. H. (2023). Kesesuaian Hasil Laboratorium dengan Klinis Bayi Sepsis Neonatorum. Jurnal Penelitian Perawat Profesional, 1677-1688.
  4. Fitriani, E. C. (2019). Hubungan Kadar dan Hitung Jenis Leukosit pada Angka Mortalitas Neonatus dan Bayi Akibat Sepsis di Kabupaten Malang. JIM Unisma, 183-189.
  5. Glaser, M. A. (2021). a review of pathophysiology and current management strategies. Advances in Neonatal Care, 49-60.
  6. Hadinegoro, S. R. (2018). Buku Ajar Infeksi dan Penyakit Tropis. Jakarta: Ikatan Dokter Anak Indonesia.
  7. Hafid, R. A. (2024). Pengaruh Pemberian Tepung Daun Kelor (Moringa Oliefera) pada Ibu Hamil terhadap Berat Badan Bayi Baru Lahir . Ners Akademika, 33-37.
  8. Hematyar, M. N. (2012). Assesing Role of Clinical Manifestation and Laboratory Findings in Neonatal Sepsis. Archive of Pediatric Infectious Disease Journal, 799-802.
  9. Hornik, C. P.-W. (2012). Use of the complete blood cell count in early-onset neonatal sepsis. The Pediatric Infectious Disease Journal, 799-802.
  10. Jaya, I. G. (2019). Hubungan prematuritas dengan kejadian sepsis neonatorum yang dirawat di ruang perinatology dan neonatal intensive care unit (NICU) RSUD Wangaya kota Denpasar. Intisari Sains Medis, 18-22.
  11. Kim, F. P. (2020). Neonatal Sepsis. BMJ (Clinical Research Ed), 371.
  12. Klingenberg, C. K. (2018). Culture-Negative Early-Onset Neonatal Sepsis- At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship. Frontiers in Pediatrics, 285.
  13. Kosim, M. S. (2018). Buku Ajar Neonatologi Anak. Jakarta: Ikatan Dokter Anak Indonesia.
  14. Medicines, E. A. (2010). Report on the Expert Meeting on Neonatal and Paediatric Sepsis.
  15. Nguyen, T. B. (2023). Clinical characteristics and laboratory test in full-term neonates with sepsis in Vietnam National Children's Hospital. Russian Journal if Infection and Immunity, 127-132.
  16. Niederman, M. S. (2021). Initial antimicrobial management of sepsis. critical care, 307.
  17. Noah, F. N. (2022). Perinatal risk factors and early onset of neonatal sepsis. International Journal of Pediatric Research, 88.
  18. Pek, J. H. (2020). Neurocognitive impairment after neonatal sepsis: Protocol for systematic review and meta-analysis. BMJ open, 0.
  19. Prasetyo, D. S. (2023). Application of a sepsis flow chip (SFC) assay for the molecular diagnosis of paediatric sepsis. access microbiology, 1.
  20. Primadevi, I. &. (2022). Hubungan Preeklamsia dengan Kejadian Bayi Berat Lahir Rendah. Ners Akademika, 17-21.
  21. Rudd, K. E. (2020). Global, regional, and national sepsis incidence and mortality. The Lancet, 32989-7.
  22. Sari, R. D. (2022). Pemberdayaan Skill dan Pengetahuan Kader Kesehatan Mengenai Penanganan Kegawatdaruratan Obstetri sebagai Upaya Menurunkan Nilai Angka Kematian Ibu (AKI) di Desa Cipadang Kecamatan Gedong Tataan Kabupaten Pesawaran . Jurnal Ilmu Medis Indonesia, 95-103.
  23. Setyoningrum, R. A. (2024). White Blood Cell Count and Neutrophil-Lymphocyte Ratio in Children with Complicated and Uncomplicated Pneumonia . Jurnal Ilmu Medis Indonesia, 1-7.
  24. Sullivan, B. A. (2022). Vital signs as physuiomarkers of neonatal sepsis. Pediatric Research, 273-282.
  25. Tam, P. Y. (2017). Diagnostics for neonatal sepsis: current approaches and future directions. Pediatric Research, 574-583.
  26. Toan, N. D. (2022). Clinical and laboratory factors associated with neonatal sepsis mortalitu at a major Vietnamese childrens's hospital. PLOS Global Public Health, 9.
  27. Tuzun, F. O. (2019). Is European Medicines Agency sepsis criteria accurate for neonatal sepsis diagnosis or do we need new criteria. Plos one, 1.
  28. Wee, B. Y. (2020). A narrative review of heart rate and variability in sepsis. Annal of Translational Meidcine, 20-148.
  29. Wynn, J. L. (2014). Time for a neonatal-spesific consensus definition for sepsis. Pediatric Critical Care Medicine, 523-528.
  30. Zea-Vera, A. &. (2015). Challanges in the diagnosis and management of neonatal sepsis. Journal of tropical pediatrics, 1-13.