Mikrobiota Usus dan Osteoartritis

https://doi.org/10.35912/jimi.v1i1.279
Published: Sep 25, 2021

Abstract:

Osteoarthritis (OA) is one of the most commonly experienced musculoskeletal diseases. Various studies were conducted to find the relationship between the gut microbiota and the incidence of osteoarthritis. The gut microbiota encourages the production of proinflammatory cytokines and bacterial metabolites which are considered to be part of the pathophysiological mechanisms of osteoarthritis. Various risk factors that trigger osteoarthritis, such as age, gender, diet, and obesity have an influence on the gut microbiota. This suggests the possible involvement of the microbiota in the incidence of osteoarthritis. The increasing prevalence of osteoarthritis calls for an effective disease-modifying therapy strategy to relieve symptoms and slow the progression of the condition. The investigators hypothesized that modulation of the gut microbiota by external approaches might influence the progression of osteoarthritis. To date, some evidence suggests that gut microbiota intervention can be realized through probiotics, prebiotics, exercise, and fecal microbiota transplantation (FMT).

Keywords: Osteoarthritis, Microbiota, Risk Factor

Keywords:
1. Osteoarthritis
2. Microbiota
3. Risk Factor
Authors:
1 . Redi Bintang Pratama
2 . Khairun Nisa Berawi
3 . Nurul Islamy
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How to Cite
Pratama, R. B., Berawi, K. N., & Islamy, N. (2021). Mikrobiota Usus dan Osteoartritis. Jurnal Ilmu Medis Indonesia, 1(1), 1–6. https://doi.org/10.35912/jimi.v1i1.279
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Issue & Section
Vol. 1 No. 1 (2021): September
Articles
References

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    Frank DN., Amand ALS., Feldman RA., Boedeker EC., Harpaz N., Pace NR. (2007). Molecular- phylogenetic characterization of microbial community imbalances in human inflamatory bowel diseases. Proceedings of the National Academy of Sciences of the United States of America,21(104), 13780–13785. https://doi.org/10.1073/pnas.0706625104

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  1. Baker KR., Matthan NR., Lichtenstein AH, Niu J., Guermazi A., Roemer F., Grainger A., Nevitt MC., Clancy M., Lewis CE,. etal. (2012). Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis and Cartilage, 20(5), 382–7.
  2. Berenbaum F., Wallace IJ., Lieberman DE., Felson DT (2018). Modern-dayenvironmentalfactors in the path ogenesisofosteoarthritis. Nature Reviews Rheumatology, 14(11), 674–81.
  3. Biver E., Berenbaum F., Valdes AM., Araujo deCarvalho I., Bindels LB., BrandiML., Calder PC., Castronovo V.,
  4. Cavalier E., Cherubini A, etal. (2019). Gut microbiot aand osteoarthritis management: ane xpert consensus of th eEuropeans ociety for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO). Ageing Research Reviews, 55, 100946.
  5. Cammarota G., Ianiro G., Tilg H., Rajilic- Stojanovic M., Kump P., Satokari R., Sokol H., Arkkila P., Pintus C,. Hart A, etal. (2017). European consensus conference on faecal microbiota transplantation in clinical practice. Gut, 66(4), 569–80.
  6. Capurso G., Lahner E. (2017). The interaction between smoking, alcohol and the gut microbiome. Best Practice &Research Clinical Gastroenterology, 31(5), 579–88.
  7. Contartese D., Tschon M., DeMattei M., Fini M. (2020), Sex specific determinants in osteoarthritis: a systematic review of preclinical studies. International Journal Molecular Sciences, 21(10), 3696. https://doi.org/10.3390/ijms21103696.
  8. Cross M., Smith E., Hoy D., Nolte S., Ackerman I., Fransen M., Bridgett L., Williams S., Guillemin F., Hill CL, etal. (2010). The global burden of hip and knee osteoarthritis: estimates from the global burden of disease study. Annals Rheumatic Diseases,73(7), 1323–30
  9. de Oliveira GLV., Leite AZ., Higuchi BS., Gonzaga MI., Mariano VS. (2017). Intestinal dysbiosis and probiotic applications in autoimmune diseases. Immunology, 152(1),1–12
  10. Frank DN., Amand ALS., Feldman RA., Boedeker EC., Harpaz N., Pace NR. (2007). Molecular- phylogenetic characterization of microbial community imbalances in human inflamatory bowel diseases. Proceedings of the National Academy of Sciences of the United States of America,21(104), 13780–13785. https://doi.org/10.1073/pnas.0706625104
  11. Guss JD., Ziemian SN., Luna M., Sandoval TN., Holyoak DT., Guisado GG., Roubert S., Callahan RL., Brito IL., vanderMeulen MCH., etal. (2019). The effects of metabolic syndrome, obesity, and the gut microbiomeon load- induced osteoarthritis. Osteoarthritis Cartilage, 27(1), 129–39.
  12. Guss JD., Ziemian SN., Luna M., Sandoval TN., Holyoak DT., Guisado GG., Roubert S., Callahan R.L, Brito IL, vanderMeulen MCH, etal. (2019). The effects of metabolic syndrome, obesity, and the gut microbiome on load- induced osteoarthritis. Osteoarthritis Cartilage, 27(1),129–39.
  13. Li JY., Chassaing B., Tyagi AM., Vaccaro C., Luo T., Adams J., Darby TM, Weitzmann MN., Mulle JG., Gewirtz AT., etal. (2016). Sex steroid deficiency associated bone loss is microbiota dependent and prevented by probiotics. The Journal of Clinical Investigation, 126(6),2049–63.
  14. Markowiak P., Slizewska K. (2017). Effects of probiotics, prebiotics, and synbioticson human health. Nutrients, 1021. https://doi.org/10.3390/nu9091021.
  15. Mills S, Stanton C., Lane JA., Smith GJ., Ross RP.(2019). Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients, 11(4):923.https://doi.org/10.3390/nu11040923.
  16. Monda V., Villano I., Messina A., Valenzano A., Esposito T., Moscatelli F., Viggiano A., Cibelli G., Chieffi S., Monda M., etal. (2017). Exercise modifies the gut microbiota with positive health effects. Oxidative Medicine and Cellular Longevity, 3831972.
  17. Oliveria SA., Felson DT., Reed JI., Cirillo PA., Walker AM. (1995). Incidence of symptomatic and, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheumatism, 38(8), 1134–41
  18. Rios JL., Bomhof MR., Reimer RA., Hart DA., Collins KH., Herzog W. (2019). Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-inducedobesity. Scientific Reports, 9(1),3893.
  19. Tap J,Mondot S., Levenez F., Pelletier E., Caron C., Furet JP., Ugarte E., Muñoz-Tamayo R., Paslier DLE., Nalin R., Dore J., Leclerc M. (2009) Towards the human intestinal microbiota phylogenetic core. Environmental Microbiology, 11, 574–2584. https://doi.org/10.1111/j.1462- 2920.2009.01982.x
  20. Thomas S., Browne H., Mobasheri A., Rayman MP. (2018). Whatis the evidence for a rolefor diet and nutrition in osteoarthritis?. Rheumatology, 57(4), 61–74.
  21. Yucesoy B., Charles LE., Baker B., Burchfiel CM. (2015). Occupational and genetic risk factors for osteoarthritis: a review. IOS Press. .50(2),261–73.
  22. Zhang W., Moskowitz RW., Nuki G., Abramson S., Altman RD., Arden N., Bierma-Zeinstra S., Brandt KD., Croft P., Doherty M., etal. (2008). OARSI recommendations for the management of hip and knee osteoarthritis, part II: OARSI evidence based, expert consensus guidelines. Osteoarthritis and Cartilage, 16(2), 37–62.