Potensi Senyawa Turunan Terpenoid sebagai Agen Anti-Kanker

https://doi.org/10.35912/jimi.v4i1.4551
Published: Sep 15, 2024

Abstract:

Purpose: This study aimed to analyze the potential of terpenoid derivatives as anti-cancer agents by reviewing various molecular mechanisms involved, findings from preclinical and clinical studies, and the challenges faced in their development.

Methodology: A literature review approach was used, involving the collection, analysis, and synthesis of data from credible sources, to present a comprehensive understanding of the pharmacological properties and mechanisms of action of terpenoids. Critical evaluation of the selected studies was carried out to identify key findings and trends..

Results: This review shows that terpenoids have significant potential in cancer therapy through diverse molecular mechanisms, both as monotherapies and in combination with conventional treatments. Advances in drug delivery technologies, such as the use of nanoparticles and liposomes, have enhanced the stability and bioavailability of compounds, paving the way for more effective therapeutic applications.

Conclusions: Terpenoid-based drug development shows strong promise in cancer treatment. Structural modifications have improved their efficacy and selectivity toward cancer cells, and innovative delivery systems have addressed challenges in bioavailability, supporting their role as safe and effective therapeutic alternatives.

Limitations: This review was based on secondary data and lacked direct clinical validation. It does not provide detailed pharmacokinetic or pharmacodynamic profiles, and its potential interactions with standard chemotherapeutic agents remain underexplored.

Contribution: This article synthesizes the molecular mechanisms and therapeutic potential of terpenoid derivatives as anticancer agents. This highlights the advances in delivery technologies and structural optimization, offering valuable insights for future drug development strategies.

Keywords:
1. Agent Anticancer
2. Cancer
3. Chemistry Medicinal
4. Mechanism Molecular
5. Terpenoid
Authors:
1 . Saeful Amin
2 . Galuh Taruna Supriatna
3 . Mohamad Idwar Ardian
4 . Muhammad Iqmal Abdurrahman
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How to Cite
Amin, S. ., Supriatna, G. T., Ardian, M. I. ., & Abdurrahman, M. I. . (2024). Potensi Senyawa Turunan Terpenoid sebagai Agen Anti-Kanker. Jurnal Ilmu Medis Indonesia, 4(1), 53–61. https://doi.org/10.35912/jimi.v4i1.4551
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Issue & Section
Vol. 4 No. 1 (2024): September
Articles
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References

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    Amin, S., Cahya, N. A., Rachmat, S. W., Adri, & Amelya, I. N. (2024). Tanaman Lingkungan Sebagai Penyembuhan Penyakit. Jambi: PT. Sonpedia Publishing Indonesia.

    Amin, S., Hurry, Z. A. Z., Sumantri, T. A., & Fauzi, R. A. (2024). Studi Komputasional Senyawa Flavonoid Tanaman Obat sebagai Kandidat Agen Antidiabetik. Jurnal Ilmu Medis Indonesia, 4(1), 21-40. doi:10.35912/jimi.v4i1.4553

    Amin, S., Muhtar, N. L. N., Kaamilah, D., & Yulianingsih, T. S. (2024). Studi In Silico Senyawa Daun Salam Sebagai Antidiabetes Melalui Mekanisme Inhibitor SGLT-2 (In Silico Study of Bay Leaf Compounds as Antidiabetic Agents via SGLT-2 Inhibition Mechanism). Jurnal Ilmu Medis Indonesia (JIMI), 4(1). doi:https://doi.org/10.35912/jimi.v4i1.4539

    Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, Y. S. (2024). Potensi Senyawa Kuersetin sebagai Antikanker Payudara melalui Pendekatan Molecular Docking. Jurnal Ilmu Medis Indonesia, 4(1), 41-51. doi:10.35912/jimi.v4i1.4565

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    Gustaman, F., Amin, S., Nurdianti, L., Wulandari, W. T., Idacahyati, K., & Nurlathifah, L. (2022). Antioxidant Activity of Effervescent Granules from Kirinyuh Leaves (Chromolaena odorata (L.) RM King and H. Rob) and Leaf of Mareme (Glochidion arborescens Blume). International Journal of Applied Pharmaceutics, 14(4), 86-91. doi:https://doi.org/10.22159/ijap.2022.v14s4.pp13

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    Mabou, F. D., & Yossa, I. B. N. (2021). TERPENES: Structural Classification and Biological Activities. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), 16(3), 25-40. doi:https://doi.org/10.9790/3008-1603012540

    Maswal, M., Pandita, M., & Bashir, S. (2023). Terpenes, Terpenoids and Steroids: Properties, Biosynthesis and Functions. In A. H. Banday (Ed.), Steroids and Their Medicinal Potential (pp. 1-38). United Arab Emirates: Bentham Science Publishers.

    Masyita, A., Sari, R. M., Astuti, A. D., Yasir, B., Rumata, N. R., Emran, T. B., . . . Simal-Gandara, J. (2022). Terpenes and Terpenoids as Main Bioactive Compounds of Essential Oils, Their Roles in Human Health and Potential Application as Natural Food Preservatives. Food chemistry: X, 13, 1-14. doi:https://doi.org/10.1016/j.fochx.2022.100217

    Mishra, P., Rafi, Z., Faruqui, T., Mansoor, S., Ahmad, I., Ahmad, I., . . . Saeed, M. (2024). Exploring the Significance and Cutting-Edge Applications of Terpenes and Terpenoid-Derived Inorganic Nanoparticles. Science of Advanced Materials, 16(6), 665-681. doi:https://doi.org/10.1166/sam.2024.4688

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    Su, S., Yang, X.-Q., Yang, Y.-B., & Ding, Z.-T. (2023). Antifungal and antifeedant terpenoids from Paraphaeosphaeria sp. cultured by extract of host Ginkgo biloba. Phytochemistry, 210, 113651. doi:https://doi.org/10.1016/j.phytochem.2023.113651

    Sun, H., Zhang, L., Sui, B., Li, Y., Yan, J., Wang, P., . . . Liu, S. (2021). The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment. Evidence?Based Complementary and Alternative Medicine, 1-13. doi:https://doi.org/10.1155/2021/3730963

    Syalsabila, D. P., & Manafe, C. J. W. (2024). Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review. Jurnal Biologi Tropis, 24(1), 327-334. doi:https://doi.org/10.29303/jbt.v24i1b.7950

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    Zeng, L., Gowda, B. J., Ahmed, M. G., Abourehab, M. A., Chen, Z.-S., Zhang, C., . . . Kesharwani, P. (2023). Advancements in Nanoparticle-Based Treatment Approaches for Skin Cancer Therapy. Molecular Cancer, 22(1), 1-50. doi:https://doi.org/10.1186/s12943-022-01708-4

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  1. Adelia, G., & Puswati, D. (2024). Penerapan Terapi Minyak Zaitun Terhadap Gangguan Integritas Kulit pada Pasien Anak. Science: Indonesian Journal of Science, 1(3), 282-289. doi:https://doi.org/10.31004/science.v1i3.53
  2. Agallou, M., Margaroni, M., Tsanaktsidou, E., Badounas, F., Kammona, O., Kiparissides, C., & Karagouni, E. (2023). A liposomal vaccine promotes strong adaptive immune responses via dendritic cell activation in draining lymph nodes. Journal of Controlled Release, 356, 386-401. doi:https://doi.org/10.1016/j.jconrel.2023.03.006
  3. Ahmad, A. R., Amaliah, A., Abidin, Z., Razak, R., & Malik, A. (2024). Pengembangan Obat Bahan Alam (Essential Oil). Cilacap: Nas Media Pustaka.
  4. Amin, S., Cahya, N. A., Rachmat, S. W., Adri, & Amelya, I. N. (2024). Tanaman Lingkungan Sebagai Penyembuhan Penyakit. Jambi: PT. Sonpedia Publishing Indonesia.
  5. Amin, S., Hurry, Z. A. Z., Sumantri, T. A., & Fauzi, R. A. (2024). Studi Komputasional Senyawa Flavonoid Tanaman Obat sebagai Kandidat Agen Antidiabetik. Jurnal Ilmu Medis Indonesia, 4(1), 21-40. doi:10.35912/jimi.v4i1.4553
  6. Amin, S., Muhtar, N. L. N., Kaamilah, D., & Yulianingsih, T. S. (2024). Studi In Silico Senyawa Daun Salam Sebagai Antidiabetes Melalui Mekanisme Inhibitor SGLT-2 (In Silico Study of Bay Leaf Compounds as Antidiabetic Agents via SGLT-2 Inhibition Mechanism). Jurnal Ilmu Medis Indonesia (JIMI), 4(1). doi:https://doi.org/10.35912/jimi.v4i1.4539
  7. Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, Y. S. (2024). Potensi Senyawa Kuersetin sebagai Antikanker Payudara melalui Pendekatan Molecular Docking. Jurnal Ilmu Medis Indonesia, 4(1), 41-51. doi:10.35912/jimi.v4i1.4565
  8. Astuti, H., Sari, M. R., Madinah, M., & Murni, D. (2024). Analisis Faktor yang Berhubungan dengan Perilaku Deteksi Dini Kanker Serviks dan Kanker Payudara. Science: Indonesian Journal of Science, 1(1), 20-29. doi:https://doi.org/10.31004/science.v1i1.6
  9. Attri, K., Sharda, D., Chudasama, B., Mahajan, R. L., & Choudhury, D. (2023). A Review on Terpenes for Treatment of Gastric Cancer: Current Status and Nanotechnology-Enabled Future. RSC Sustainability, 1(5), 1109-1124. doi:https://doi.org/10.1039/D2SU00137C
  10. Bray, F., Laversanne, M., Weiderpass, E., & Soerjomataram, I. (2021). The Ever?Increasing Importance of Cancer as a Leading Cause of Premature Death Worldwide. Cancer: An International Interdisciplinary Journal of the American Cancer Society, 127(16), 3029-3030. doi:https://doi.org/10.1002/cncr.33587
  11. Brown, J. S., Amend, S. R., Austin, R. H., Gatenby, R. A., Hammarlund, E. U., & Pienta, K. J. (2023). Updating the Definition of Cancer. Molecular Cancer Research, 21(11), 1142-1147. doi:https://doi.org/10.1158/1541-7786.MCR-23-0411
  12. Carsanba, E., Pintado, M., & Oliveira, C. (2021). Fermentation Strategies for Production of Pharmaceutical Terpenoids in Engineered Yeast. Pharmaceuticals, 14(4), 1-29. doi:https://doi.org/10.3390/ph14040295
  13. Chopra, B., Dhingra, A. K., Dhar, K. L., & Nepali, K. (2021). Emerging Role of Terpenoids for the Treatment of Cancer: A Review. Mini Reviews in Medicinal Chemistry, 21(16), 2300-2336. doi:https://doi.org/10.2174/1389557521666210112143024
  14. El-Baba, C., Baassiri, A., Kiriako, G., Dia, B., Fadlallah, S., Moodad, S., & Darwiche, N. (2021). Terpenoids’ Anti-Cancer Effects: Focus on Autophagy. Apoptosis, 26(9), 491-511. doi:https://doi.org/10.1007/s10495-021-01684-y
  15. Garcia-Oliveira, P., Otero, P., Pereira, A. G., Chamorro, F., Carpena, M., Echave, J., . . . Prieto, M. A. (2021). Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment. Pharmaceuticals, 14(2), 1-28. doi:https://doi.org/10.3390/ph14020157
  16. Gustaman, F., Amin, S., Nurdianti, L., Wulandari, W. T., Idacahyati, K., & Nurlathifah, L. (2022). Antioxidant Activity of Effervescent Granules from Kirinyuh Leaves (Chromolaena odorata (L.) RM King and H. Rob) and Leaf of Mareme (Glochidion arborescens Blume). International Journal of Applied Pharmaceutics, 14(4), 86-91. doi:https://doi.org/10.22159/ijap.2022.v14s4.pp13
  17. Issusilaningtyas, E., Yulianto, A. N., Rochmah, N. N., Pertiwi, Y., Faoziyah, A. R., Sari, W. Y., & Balfas, R. F. (2024). Teknologi Farmasi Bahan Alam. Makassar: CV. Tohar Media.
  18. Kamran, S., Sinniah, A., Abdulghani, M. A., & Alshawsh, M. A. (2022). Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers, 14(5), 1-46. doi:https://doi.org/10.3390/cancers14051100
  19. Khan, F., Pandey, P., Verma, M., & Upadhyay, T. (2024). Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies. Biomolecules, 14(2), 1-25. doi:https://doi.org/10.3390/biom14020200
  20. Li, Z., Zhu, Y.-t., Xiang, M., Qiu, J.-l., Luo, S.-q., & Lin, F. (2021). Enhanced Lysosomal Function is Critical for Paclitaxel Resistance in Cancer Cells: Reversed by Artesunate. Acta Pharmacologica Sinica, 42(4), 624-632. doi:https://doi.org/10.1038/s41401-020-0445-z
  21. Liang, J. L., Luo, G. F., Chen, W. H., & Zhang, X. Z. (2021). Recent Advances in Engineered Materials for Immunotherapy-Involved Combination Cancer Therapy. Advanced Materials, 33(31).
  22. Mabou, F. D., & Yossa, I. B. N. (2021). TERPENES: Structural Classification and Biological Activities. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), 16(3), 25-40. doi:https://doi.org/10.9790/3008-1603012540
  23. Maswal, M., Pandita, M., & Bashir, S. (2023). Terpenes, Terpenoids and Steroids: Properties, Biosynthesis and Functions. In A. H. Banday (Ed.), Steroids and Their Medicinal Potential (pp. 1-38). United Arab Emirates: Bentham Science Publishers.
  24. Masyita, A., Sari, R. M., Astuti, A. D., Yasir, B., Rumata, N. R., Emran, T. B., . . . Simal-Gandara, J. (2022). Terpenes and Terpenoids as Main Bioactive Compounds of Essential Oils, Their Roles in Human Health and Potential Application as Natural Food Preservatives. Food chemistry: X, 13, 1-14. doi:https://doi.org/10.1016/j.fochx.2022.100217
  25. Mishra, P., Rafi, Z., Faruqui, T., Mansoor, S., Ahmad, I., Ahmad, I., . . . Saeed, M. (2024). Exploring the Significance and Cutting-Edge Applications of Terpenes and Terpenoid-Derived Inorganic Nanoparticles. Science of Advanced Materials, 16(6), 665-681. doi:https://doi.org/10.1166/sam.2024.4688
  26. Nakamura, M., & Jang, I.-S. (2021). Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons. European Journal of Pharmacology, 910, 174449. doi:https://doi.org/10.1016/j.ejphar.2021.174449
  27. Nugroho, L. H., & Hartini, Y. S. (2021). Farmakognosi Tumbuhan Obat: Kajian Spesifik Genus Piper. Yogyakarta: Gadjah Mada University Press.
  28. Peng, S., Yuan, X., Li, H., Wei, Y., Zhou, B., Ding, G., & Bai, J. (2023). Recent progress in nanocarrier-based drug delivery systems for antitumour metastasis. European journal of medicinal chemistry, 252, 115259. doi:https://doi.org/10.1016/j.ejmech.2023.115259
  29. Rahmawati, N. (2021). Efek Kombinasi Ekstrak Etil Asetat Daun Faloak (Sterculia quadrifida R. Br) dan Paclitaxel Terhadap Peningkatan Kematian Sel dan Penurunan Aktivitas Migrasi Sel Kanker Serviks. Universitas Brawijaya, Malang. Retrieved from https://repository.ub.ac.id/id/eprint/185514
  30. Ridwan, & Kaharudin, L. O. (2022). Identifikasi dan Uji Kandungan Metabolit Sekunder Tumbuhan Obat. Jurnal Ilmiah Biosaintropis (Bioscience-Tropic), 7(2), 46-56. doi:https://doi.org/10.33474/e-jbst.v7i2.467
  31. Roy, S., Ghosh, A., Majie, A., Karmakar, V., Das, S., Dinda, S. C., . . . Gorain, B. (2024). Terpenoids as Potential Phytoconstituent in the Treatment of Diabetes: From Preclinical to Clinical Advancement. Phytomedicine, 129. doi:https://doi.org/10.1016/j.phymed.2024.155638
  32. Setyoningrum, R. A., Lestari, S. R., Sari, R. K., Visuddho, V., Hapsari, R., & Chafid, A. P. P. (2024). White Blood Cell Count and Neutrophil-Lymphocyte Ratio in Children with Complicated and Uncomplicated Pneumonia. Jurnal Ilmu Medis Indonesia, 4(1), 1-7.
  33. Silva, J. J. M. d., Campanharo, S. C., & Paschoal, J. A. R. (2021). Ethnoveterinary for Food?Producing Animals and Related Food Safety Issues: A Comprehensive Overview About Terpenes. Comprehensive Reviews in Food Science and Food Safety, 20(1), 48-90. doi:https://doi.org/10.1111/1541-4337.12673
  34. Su, S., Yang, X.-Q., Yang, Y.-B., & Ding, Z.-T. (2023). Antifungal and antifeedant terpenoids from Paraphaeosphaeria sp. cultured by extract of host Ginkgo biloba. Phytochemistry, 210, 113651. doi:https://doi.org/10.1016/j.phytochem.2023.113651
  35. Sun, H., Zhang, L., Sui, B., Li, Y., Yan, J., Wang, P., . . . Liu, S. (2021). The Effect of Terpenoid Natural Chinese Medicine Molecular Compound on Lung Cancer Treatment. Evidence?Based Complementary and Alternative Medicine, 1-13. doi:https://doi.org/10.1155/2021/3730963
  36. Syalsabila, D. P., & Manafe, C. J. W. (2024). Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review. Jurnal Biologi Tropis, 24(1), 327-334. doi:https://doi.org/10.29303/jbt.v24i1b.7950
  37. Yeni, Y. T. N., Wardana, F. A., & Pawana, I. P. A. (2025). Pengaruh Circuit Training terhadap Peningkatan Agility pada Pemain Futsal. Jurnal Ilmu Medis Indonesia, 4(1), 9-20. doi:10.35912/jimi.v4i1.4393
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