Evaluasi Potensi Antikanker Senyawa Daun Kelor melalui Kimia Medisinal

https://doi.org/10.35912/jimi.v4i1.4544
Published: Sep 19, 2024

Abstract:

Purpose: This study aimed to assess the potential of bioactive compounds found in moringa (Moringa oleifera) leaves as agents to treat breast cancer using a medicinal chemistry approach.

Methodology/approach: This study was conducted using a descriptive and qualitative literature review approach, utilizing data sources from various relevant scientific journals published in the last five years.

Results/findings: This study showed that four key compounds, moringin, kaempferol, quercetin, and nanoquercetin, have significant biological potential in inhibiting the growth and spread of breast cancer cells through various molecular mechanisms. The combination of these compounds provides a synergistic and selective therapeutic approach and shows potential in the development of more effective cancer therapies with minimal side effects. However, challenges related to pharmacokinetic limitations, especially in quercetin, can be overcome through technological innovations, such as nano-based delivery systems.

Conclusions: This study concludes that bioactive compounds in Moringa oleifera leaves possess promising anticancer properties against breast cancer through diverse molecular mechanisms. Their synergistic potential highlights the relevance of natural compounds in the development of selective and effective cancer therapies.

Limitations: The study was limited by its reliance on secondary data from literature sources and lack of experimental validation. Additionally, pharmacokinetic challenges, especially for quercetin, necessitate further research on delivery system optimization.

Contributions: This research adds valuable insights into the medicinal chemistry of natural compounds, particularly in the Indonesian context. It also encourages the development of innovative drug delivery technologies to enhance the clinical applications of plant-derived anticancer agents.

Keywords:
1. Bioactive Coumpounds
2. Breast Cancer
3. Medicinal Chemistry
4. Moringa Oleifera
Authors:
1 . Saeful Amin
2 . Delya Pujiyani
3 . Nisrina Putri Rusiyana
4 . Shafa Meyliana Azzahra
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How to Cite
Amin, S. ., Pujiyani, D. ., Rusiyana, N. P., & Azzahra, S. M. (2024). Evaluasi Potensi Antikanker Senyawa Daun Kelor melalui Kimia Medisinal. Jurnal Ilmu Medis Indonesia, 4(1), 75–82. https://doi.org/10.35912/jimi.v4i1.4544
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Vol. 4 No. 1 (2024): September
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References

    Referensi

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    Amin, S., Aryanti, R., & Aprilia, A. Y. (2023). Studi In Silico Senyawa yang Terkandung dalam Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Antikanker Payudara. Paper presented at the Prosiding Seminar Nasional Diseminasi Penelitian Volume 3.

    Amin, S., Supriatna, G. T., Ardian, M. I., & Abdurrahman, M. I. (2024). Potensi Senyawa Turunan Terpenoid sebagai Agen Anti-Kanker. Jurnal Ilmu Medis Indonesia, 4(1), 53-61. doi:10.35912/jimi.v4i1.4551

    Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, Y. S. (2024). Potensi Senyawa Kuersetin sebagai Antikanker Payudara melalui Pendekatan Molecular Docking. Jurnal Ilmu Medis Indonesia, 4(1), 41-51. doi:10.35912/jimi.v4i1.4565

    Banerjee, M., Nimkar, K., Naik, S., & Patravale, V. (2022). Unlocking the potential of drug-drug cocrystals–A comprehensive review. Journal of Controlled Release, 348, 456-469. doi:https://doi.org/10.1016/j.jconrel.2022.06.003

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    Heng, L., Zhao, M., Xu, R., Tao, R., Wang, C., Zhang, L., . . . Li, Y. (2021). Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss. Phytochemistry, 182, 112606. doi:https://doi.org/10.1016/j.phytochem.2020.112606

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    Khaneghahi, S., Sefatgol, S., & Siyasar, M. (2022). Investigating the relationship between school culture and academic enthusiasm with academic hope and motivation in high school students. Journal of Social, Humanity, and Education, 3(1), 29-41.

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    Mwosi, F., Eton, M., Aluonzi, B., Olupot, S. P., & Alia, R. (2024). Business partnership, women empowerment and support to women living with HIV/AIDS in Kabale, Uganda. Journal of Sustainable Tourism and Entrepreneurship, 6(1), 15-29.

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    Sodvadiya, M., Patel, H., Mishra, A., & Nair, S. (2020). Emerging insights into anticancer chemopreventive activities of nutraceutical Moringa oleifera: Molecular mechanisms, signal transduction and in vivo efficacy. Current Pharmacology Reports, 6, 38-51.

    Sultan, R., Ahmed, A., Wei, L., Saeed, H., Islam, M., & Ishaq, M. (2023). The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches. BMC Complementary Medicine and Therapies, 23(1), 396.

    Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3), 209-249.

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  1. Referensi
  2. Alotaibi, M. H., & Bahammam, S. A. (2021). Determining the correlation between comorbidities and MERS-CoV mortality in Saudi Arabia. Journal of Taibah University Medical Sciences, 16(4), 591-595. doi:https://doi.org/10.1016/j.jtumed.2021.02.003
  3. Amin, S., Aryanti, R., & Aprilia, A. Y. (2023). Studi In Silico Senyawa yang Terkandung dalam Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Antikanker Payudara. Paper presented at the Prosiding Seminar Nasional Diseminasi Penelitian Volume 3.
  4. Amin, S., Supriatna, G. T., Ardian, M. I., & Abdurrahman, M. I. (2024). Potensi Senyawa Turunan Terpenoid sebagai Agen Anti-Kanker. Jurnal Ilmu Medis Indonesia, 4(1), 53-61. doi:10.35912/jimi.v4i1.4551
  5. Amin, S., Wihdatunnisa, I., Aisyah, R., & Kurniawan, Y. S. (2024). Potensi Senyawa Kuersetin sebagai Antikanker Payudara melalui Pendekatan Molecular Docking. Jurnal Ilmu Medis Indonesia, 4(1), 41-51. doi:10.35912/jimi.v4i1.4565
  6. Banerjee, M., Nimkar, K., Naik, S., & Patravale, V. (2022). Unlocking the potential of drug-drug cocrystals–A comprehensive review. Journal of Controlled Release, 348, 456-469. doi:https://doi.org/10.1016/j.jconrel.2022.06.003
  7. Gainutdinov, T., Gizatullina, Z., Debska-Vielhaber, G., Vielhaber, S., Feldmann Jr, R. E., Orynbayeva, Z., & Gellerich, F. N. (2023). Corrigendum to" Age-associated alterations of brain mitochondria energetics"[Biochem. Biophys. Res. Commun. 643 (2023) 1-7]. Biochemical and Biophysical Research Communications, 644, 171-171. doi:https://doi.org/10.1016/j.bbrc.2023.01.015
  8. Heng, L., Zhao, M., Xu, R., Tao, R., Wang, C., Zhang, L., . . . Li, Y. (2021). Phragmalin and mexicanolide limonoids with reversal of multidrug resistance from the seeds of Chukrasia tabularis A. Juss. Phytochemistry, 182, 112606. doi:https://doi.org/10.1016/j.phytochem.2020.112606
  9. Hero, S. (2021). Faktor Risiko Kanker Payudara. Jurnal Medika Hutama, 3(01 Oktober), 1533-1537.
  10. Junias, M., Budiana, I., Adu, A. A., Wijaya, R. P. C., & Kiling, I. Y. (2021). Bioactive compounds and anticancer activities of moringa oleifera of east nusa tenggara origin. Indian Journal of Forensic Medicine & Toxicology, 15(3), 3554-3560.
  11. Khaneghahi, S., Sefatgol, S., & Siyasar, M. (2022). Investigating the relationship between school culture and academic enthusiasm with academic hope and motivation in high school students. Journal of Social, Humanity, and Education, 3(1), 29-41.
  12. Kharechkina, E. S., Nikiforova, A. B., Teplova, V. V., Odinokova, I. V., Krestinina, O. V., Baburina, Y. L., . . . Kruglov, A. G. (2019). Regulation of permeability transition pore opening in mitochondria by external NAD (H). Biochimica et Biophysica Acta (BBA)-General Subjects, 1863(5), 771-783. doi:https://doi.org/10.1016/j.bbagen.2019.01.003
  13. Loschwitz, J., Jäckering, A., Keutmann, M., Olagunju, M., Eberle, R. J., Coronado, M. A., . . . Strodel, B. (2021). Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay. Bioorganic Chemistry, 111, 104862. doi:https://doi.org/10.1016/j.bioorg.2021.104862
  14. Ma, X., Pang, J., Dong, R., Tang, C., Shu, Y., & Li, Y. (2020). Rapid prediction of multiple wine quality parameters using infrared spectroscopy coupling with chemometric methods. Journal of food composition and analysis, 91, 103509. doi:https://doi.org/10.1016/j.jfca.2020.103509
  15. Mwosi, F., Eton, M., Aluonzi, B., Olupot, S. P., & Alia, R. (2024). Business partnership, women empowerment and support to women living with HIV/AIDS in Kabale, Uganda. Journal of Sustainable Tourism and Entrepreneurship, 6(1), 15-29.
  16. Pop, O. L., Kerezsi, A. D., & Ciont, C. (2022). A comprehensive review of Moringa oleifera bioactive compounds—cytotoxicity evaluation and their encapsulation. Foods, 11(23), 3787.
  17. Putri, L. R., & Yuniarti, E. (2023). Literature Review: Effectiveness of Moringa Leaves (Moringa oleifera) to Diabetes Mellitus. Jurnal Biologi Tropis, 23(3), 369-373.
  18. Qanitah, Z., Tejasari, M., & Islami, U. (2023). Systematic Review: Khasiat Antikanker Sediaan Daun Kelor (Moringa oleifera) terhadap Pertumbuhan Kanker Paru. Paper presented at the Bandung Conference Series: Medical Science.
  19. Rajkumar, C., Ramsridhar, S., Veeraraghavan, V. P., Francis, A. P., Purushotham, M., & Mageshwari, U. (2024). Anticancer effect of Moringa oleifera in oral squamous cell carcinoma: a systematic review. Discover Oncology, 15(1), 1-11.
  20. Salhab, H. A. S., Joseph, J., & Samad, N. A. (2023). Molecular Targets Of Moringa Oleifera In Cancers (In Vitro And In Vivo): A Systematic Review. Journal of Health and Translational Medicine (JUMMEC), 46-65.
  21. Samantaray, A., Pradhan, D., Nayak, N. R., Chawla, S., Behera, B., Mohanty, L., . . . Gandhi, S. (2024). Nanoquercetin based nanoformulations for triple negative breast cancer therapy and its role in overcoming drug resistance. Discover Oncology, 15(1), 452.
  22. Shehzad, S., Pandey, R., Malhotra, P., & Gupta, D. (2021). Computational design of novel allosteric inhibitors for Plasmodium falciparum DegP. Molecules, 26(9), 2742. doi:https://doi.org/10.3390/molecules26092742
  23. Sodvadiya, M., Patel, H., Mishra, A., & Nair, S. (2020). Emerging insights into anticancer chemopreventive activities of nutraceutical Moringa oleifera: Molecular mechanisms, signal transduction and in vivo efficacy. Current Pharmacology Reports, 6, 38-51.
  24. Sultan, R., Ahmed, A., Wei, L., Saeed, H., Islam, M., & Ishaq, M. (2023). The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches. BMC Complementary Medicine and Therapies, 23(1), 396.
  25. Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians, 71(3), 209-249.
  26. Wee, M. K., Cabantog, J., Magpayo, D. D., Sabido, N. L., Samson, E., & David, P. (2021). Factors causing vaccine hesitancy among parents in Bulacan. Studies in Medicine and Public Health, 1(1), 15-29.

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