The Effect of Snail Mucus (Achatina fulica) on Wound Healing after Tooth Extraction: A Literature Review

https://doi.org/10.35912/jimi.v3i1.2320
Published: Sep 8, 2023

Abstract:

Purpose: Tooth extraction is a frequently performed procedure within the field of dentistry, which results in a wound. The wound healing process can be enhanced by chemical and traditional medicines, one of which is snail mucus, which contains active compounds that play an important role in wound healing process. This study aims to further discuss regarding the effect of snail mucus on wound healing process after tooth extraction.

Methodology/approach: This literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines through PubMed, ProQuest, and Google Scholar database.

Results/findings: Snail mucus contains active compounds, such as protein, glycosaminoglycans, metal elements, allantoin, sulfates, calcium, mytimacin-AF, collagen, elastin, glycolic acid, hyaluronic acid, glutathione and vitamins which have effectiveness in enhancing the wound healing process with different mechanisms for each compound, both hemostasis, inflammation, proliferation, and remodeling processes.

Limitation: The limitation of this literature review is the lack of high-quality research. Furthermore, the lack of information on the specific doses of snail mucus used and the duration of treatment are critical difficulties that should be addressed in future research to allow for more comprehensive meta-analysis. Additionally, it is required to conduct testing and comparative analysis of the composition of snail mucus across other species in order to ascertain the efficacy of snail mucus content in species other than Achatina fulica.

Contribution: The results of this literature review are expected to be a reference in scientific development of wound treatment using traditional medicine, particularly snail mucus. Additionally, it is expected to increase the understanding regarding the effect of snail mucus on wound healing after tooth extraction.

Keywords:
1. Snail mucus
2. Tooth extraction
3. Traditional medicine
4. wound healing
Authors:
1 . Fiki Muhammad Ridho
https://orcid.org/0000-0002-0187-8160
2 . Adhe Retnantya Pamungkas
3 . Ahmad Faisal
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How to Cite
Ridho, F. M., Pamungkas, A. R., & Faisal, A. (2023). The Effect of Snail Mucus (Achatina fulica) on Wound Healing after Tooth Extraction: A Literature Review. Jurnal Ilmu Medis Indonesia, 3(1), 17–30. https://doi.org/10.35912/jimi.v3i1.2320
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Vol. 3 No. 1 (2023): September
Articles
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References

    Andersson, L., Kahnberg, K.-E., and Pogrel, M. A. (2010). Oral and Maxillofacial Surgery. Wiley-Blackwell.

    Anggraeni, D. (2018). Profil dan Daya Antimikroba Lendir Bekicot (Achatina fulica) terhadap Methicillin Resistant Staphylococcus aureus (MRSA). Universitas Muhamadiyah Semarang.

    Araújo, M. G., Silva, C. O., Misawa, M., and Sukekava, F. (2015). Alveolar socket healing: what can we learn? Periodontology 2000, 68(1), 122–134. https://doi.org/10.1111/prd.12082

    Bryant, R. A., and Nix, D. P. (2016). Acute & Chronic Wounds: Current Management Concepts (5th ed.). Elsevier.

    Cañedo-Dorantes, L., and Cañedo-Ayala, M. (2019). Skin Acute Wound Healing: A Comprehensive Review. International Journal of Inflammation, 2019. https://doi.org/10.1155/2019/3706315

    Choi, J., Park, Y. G., Yun, M. S., and Seol, J. W. (2018). Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process. Biomedicine & Pharmacotherapy, 106, 326–332. https://doi.org/10.1016/J.BIOPHA.2018.06.141

    Damayanti, N., Prasetyo, A. P., Fadillah, N., Safitri, A., Perdana, R., Setiawan, E., and Ujilestari, T. (2020). Analisis Lendir Bekicot Sebagai Obat Alternatif Bagi Manusia. NECTAR: JURNAL PENDIDIKAN BIOLOGI, 1(2), 9–13.

    Deng, T., Gao, D., Song, X., Zhou, Z., Zhou, L., Tao, M., Jiang, Z., Yang, L., Luo, L., Zhou, A., Hu, L., Qin, H., and Wu, M. (2023). A natural biological adhesive from snail mucus for wound repair. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-35907-4

    Dewi, P. S., and DS, S. (2020). Lendir Bekicot Meningkatkan Jumlah Sel Makrofag pada Penyembuhan Luka Pasca Pencabutan Gigi Marmut. Interdent.Jkg., 16(1).

    El Zawawy, N. A., El-Shenody, R. A., Ali, S. S., and El-Shetehy, M. (2020). A novel study on the inhibitory effect of marine macroalgal extracts on hyphal growth and biofilm formation of candidemia isolates. Scientific Reports, 10(1), 9339. https://doi.org/10.1038/s41598-020-66000-1

    EL-Zawawy, N. A., and Mona, M. M. (2021). Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-03664-3

    Gmur, M. K., and Karpi?ski, T. M. (2020). Povidone-iodine in wound healing and prevention of wound infections. European Journal of Biological Research, 10(3), 232–239. https://doi.org/10.5281/zenodo.3958220

    Gonzalez, A. C. D. O., Andrade, Z. D. A., Costa, T. F., and Medrado, A. R. A. P. (2016). Wound healing - A literature review. Anais Brasileiros de Dermatologia, 91(5), 614–620. https://doi.org/10.1590/abd1806-4841.20164741

    Gugliandolo, E., Cordaro, M., Fusco, R., Peritore, A. F., Siracusa, R., Genovese, T., D’Amico, R., Impellizzeri, D., Di Paola, R., Cuzzocrea, S., and Crupi, R. (2021). Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice. Scientific Reports, 11(1), 3638. https://doi.org/10.1038/s41598-021-83170-8

    Gugliandolo, E., Macrì, F., Fusco, R., Siracusa, R., D’amico, R., Cordaro, M., Peritore, A. F., Impellizzeri, D., Genovese, T., Cuzzocrea, S., Di Paola, R., Licata, P., and Crupi, R. (2021). The protective effect of snail secretion filtrate in an experimental model of excisional wounds in mice. Veterinary Sciences, 8(8). https://doi.org/10.3390/vetsci8080167

    Harti, A. S., Sulisetyawati, S. D., Murharyati, A., Oktariani, M., and Wijayanti, I. B. (2016). The Effectiveness of Snail Slime and Chitosan in Wound Healing. International Journal of Pharma Medicine and Biological Sciences. https://doi.org/10.18178/ijpmbs.5.1.76-80

    Ilodigwe, E., Ndunagu, L., Ajaghaku, D., and Utoh-Nedosa, U. (2012). Evaluation of the Wound Healing Activity of a Polyherbal Remedy. Annals of Biological Research, 3(11), 5393–5398. www.scholarsresearchlibrary.com

    Jeong, J., Toida, T., Muneta, Y., Kosiishi, I., Imanari, T., Linhardt, R. J., Choi, H. S., Wu, S. J., and Kim, Y. S. (2001). Localization and characterization of acharan sulfate in the body of the giant African snail Achatina fulica. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 130(4), 513–519. https://doi.org/10.1016/S1096-4959(01)00468-7

    Kermedchiev, M., Lazarova, M., Tancheva, L., Uzunova, D., Tasheva, K., Velkova, L., Dolashki, A., Daskalova, A., Atanasov, V., Kaynarov, D., and Dolashka, P. (2021). Natural substances with therapeutic potential in wound healing. Bulgarian Chemical Communications, 53, 2021. https://doi.org/10.34049/bcc.53.?.0015

    Kesumaningrum, W., and Indriyanti, R. A. (2021). Perbandingan Efek Getah Tanaman Jarak Pagar (Jatropha Curcas L) dengan Lendir Bekicot (Achantina Fulica) terhadap Lama Penyembuhan Luka pada Mencit Jantan Galur Swiss Webster. Jurnal Riset Kedokteran, 1(1), 32–37. https://doi.org/10.29313/jrk.v1i1.314

    Khan, M. A. O., Ramadugu, R., Suvvari, T. K., M, V., and Thomas, V. (2023). Irritant contact dermatitis due to povidone-iodine following a surgical intervention: An unusual case report. SAGE Open Medical Case Reports, 11, 1–3. https://doi.org/10.1177/2050313X231185620

    Landén, N. X., Li, D., and Ståhle, M. (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences, 73(20), 3861–3885. https://doi.org/10.1007/s00018-016-2268-0

    Langdon, J., Patel, M., Ord, R., and Brennan, P. (2011). Operative Oral and Maxillofacial Surgery (2nd ed.). Hodder Arnold.

    Mardiyantoro, F. (2018). Penyembuhan Luka Rongga Mulut. UB Press.

    McDermott, M., Cerullo, A. R., Parziale, J., Achrak, E., Sultana, S., Ferd, J., Samad, S., Deng, W., Braunschweig, A. B., and Holford, M. (2021). Advancing Discovery of Snail Mucins Function and Application. In Frontiers in Bioengineering and Biotechnology (Vol. 9). Frontiers Media S.A. https://doi.org/10.3389/fbioe.2021.734023

    Miloro, M., Ghali, G. E., Larsen, P. E., and Waite, P. D. (2011). Peterson’s Principles of Oral and Maxillofacial Surgery (3rd ed.). People’s Medical Publishing House.

    Moore, U. J. (2011). Principles of Oral and Maxillofacial Surgery (6th ed.). Wiley-Blackwell.

    Mulholland, B., Tuft, S. J., and Khaw, P. T. (2005). Matrix metalloproteinase distribution during early corneal wound healing. Eye, 19(5), 584–588. https://doi.org/10.1038/sj.eye.6701557

    Olczyk, P., Mencner, ?., and Komosinska-Vassev, K. (2015). Diverse Roles of Heparan Sulfate and Heparin in Wound Repair. BioMed Research International, 2015, 1–7. https://doi.org/10.1155/2015/549417

    Oroh, C. G., Pangemanan, D. H. C., and Mintjelungan, C. N. (2015). Efektivitas Lendir Bekicot (Achatina fulica) Terhadap Jumlah Sel Fibroblas pada Luka Pasca Pencabutan Gigi Tikus Wistar. Jurnal E-Gigi (EG), 3(2), 515–520.

    Pitt, S. J., Graham, M. A., Dedi, C. G., Taylor-Harris, P. M., and Gunn, A. (2015). Antimicrobial properties of mucus from the brown garden snail Helix aspersa. British Journal of Biomedical Science, 72(4), 174–181. https://doi.org/10.1080/09674845.2015.11665749

    Primadina, N., Basori, A., and Perdanakusuma, D. S. (2019). Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler. Qanun Medika, 3(1), 31–43.

    Purnasari, P. W., Fatmawati, D., and Yusuf, I. (2012). Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus). Sains Medika?: Jurnal Kedokteran Dan Kesehatan, 4(2), 195. https://doi.org/10.30659/sainsmed.v4i2.376

    Putra, M. A. (2015). Efektivitas Pemberian Lendir Bekicot 100% (Achatina fulica) dan Sediaan Krim 5% Terhadap Lama Penyembuhan Luka Bakar Derajat II (A) Secara In Vivo. Sekolah Tinggi Ilmu Kesehatan Kusuma Husada Surakarta.

    Putri, S. A., and Ismardianita, E. (2016). The effect of ethanol extract of sarang semut plant (Hypnophytum formicarum) to angiogenesis for wound healing after teeth extraction experimental research on marmot (Cavia cobaya). Padjadjaran Journal of Dentistry, 28(3), 177–182.

    Ricci, A., Gallorini, M., Feghali, N., Sampò, S., Cataldi, A., and Zara, S. (2023). Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts. Molecules, 28(3). https://doi.org/10.3390/molecules28031222

    Riyani, N. J., Pasaribu, R., and Mardiyantoro, F. (2021). Evaluasi Jumlah Limfosit Pasca Aplikasi Lendir Bekicot (Achatina fulica) Pada Soket Tikus Wistar (Rattus norvegicus). Sinnun Maxillofacial Journal, 3(1), 42–49.

    Rosanto, Y. B., Hasan, C. Y., LNU, R., and Surya, A. (2022). The Potential of Snail (Achatina Fulica) Mucus Gel as a Phythopharmaca to Accelerate the Inflammation Process during Wound Healing. World Journal of Dentistry, 13(3), 224–227. https://doi.org/10.5005/jp-journals-10015-2056

    Rosanto, Y. B., Hasan, C. Y., Rahardjo, R., and Pangestiningsih, T. W. (2021). Effect of snail mucus on angiogenesis during wound healing. F1000Research, 10, 181. https://doi.org/10.12688/f1000research.51297.1

    Santana, W. A., Melo, C. M. de, Cardoso, J. C., Pereira-Filho, R. N., Rabelo, A. S., Reis, F. P., and Albuquerque-Júnior, R. L. C. de. (2012). Assessment of Antimicrobial Activity and Healing Potential of Mucous Secretion of Achatina fulica. International Journal of Morphology, 30(2), 365–373. https://doi.org/10.4067/S0717-95022012000200001

    Shoviantari, F., Fajriyah, S., Agustin, E., and Khairani, S. (2021). Uji Aktivitas Gel Lendir Bekicot (Achatina fulica) Sebagai Penyembuhan Luka Sayat. As-Syifaa Jurnal Farmasi, 13(1), 12–19.

    Song, Y., Cui, Y., Hao, L., Zhu, J., Yi, J., Kang, Q., Huang, J., and Lu, J. (2021). Wound-healing activity of glycoproteins from white jade snail (Achatina fulica) on experimentally burned mice. International Journal of Biological Macromolecules, 175, 313–321. https://doi.org/10.1016/j.ijbiomac.2021.01.193

    Suarni, E., and Badri, P. R. A. (2016). Uji Efektifitas Lendir Bekicot (Achatina Fulica) Dibandingkan dengan Povidon Iodine 10% terhadap Penyembuhan Luka Sayat (Vulnus Scissum) pada Mencit (Mus musculus). Syifa’MEDIKA, 7(1), 9–15.

    Trapella, C., Rizzo, R., Gallo, S., Alogna, A., Bortolotti, D., Casciano, F., Zauli, G., Secchiero, P., and Voltan, R. (2018). HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-35816-3

    Usman, A. R., and Salikunna, N. A. (2015). Pengaruh Lendir Bekicot (Achatina fulica) terhadap Waktu Penutupan Luka Sayat (Vulnus scissum) pada Mencit (Mus musculus). MEDIKA TADAKULO, 2(1), 31–39.

    Vassilev, N. G., Simova, S. D., Dangalov, M., Velkova, L., Atanasov, V., Dolashki, A., and Dolashka, P. (2020). An 1H NMR- and MS-Based Study of Metabolites Profiling of Garden Snail Helix aspersa Mucus. Metabolites, 10(9), 360. https://doi.org/10.3390/metabo10090360

    Velnar, T., Bailey, T., and Smrkolj, V. (2009). The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms. Journal of International Medical Research, 37(5), 1528–1542. https://doi.org/10.1177/147323000903700531

    Vieira, T. C. R. G., Costa-Filho, A., Salgado, N. C., Allodi, S., Valente, A.-P., Nasciutti, L. E., and Silva, L.-C. F. (2004). Acharan sulfate, the new glycosaminoglycan from Achatina fulica Bowdich 1822. European Journal of Biochemistry, 271(4), 845–854. https://doi.org/10.1111/j.1432-1033.2004.03989.x

    Waluga-Koz?owska, E., Jasik, K., Wcis?o-Dziadecka, D., Przemys?aw, P. O. L., Ku?nik-Trocha, K., Komosi?ska-Vassev, K., Olczyk, K., Waluga, M., Olczyk, P., and Zimmermann, A. (2021). Snail Mucus - A Natural Origin Substance with Potential Use in Medicine. Acta Poloniae Pharmaceutica - Drug Research, 78(6), 793–800. https://doi.org/10.32383/appdr/145377

    World Health Organization (2013). WHO Traditional Medicine Strategy: 2014-2023. World Health Organization.

    Zizioli, D., Mastinu, A., Muscò, A., Bonini, S. A., Finazzi, D., Avisani, R., Kron Morelli, G. B., Pecorelli, S., and Memo, M. (2022). Pro-Angiogenetic Effects of Purified Extracts from Helix aspersa during Zebrafish Development. Current Issues in Molecular Biology, 44(8), 3364–3377. https://doi.org/10.3390/cimb44080232

  1. Andersson, L., Kahnberg, K.-E., and Pogrel, M. A. (2010). Oral and Maxillofacial Surgery. Wiley-Blackwell.
  2. Anggraeni, D. (2018). Profil dan Daya Antimikroba Lendir Bekicot (Achatina fulica) terhadap Methicillin Resistant Staphylococcus aureus (MRSA). Universitas Muhamadiyah Semarang.
  3. Araújo, M. G., Silva, C. O., Misawa, M., and Sukekava, F. (2015). Alveolar socket healing: what can we learn? Periodontology 2000, 68(1), 122–134. https://doi.org/10.1111/prd.12082
  4. Bryant, R. A., and Nix, D. P. (2016). Acute & Chronic Wounds: Current Management Concepts (5th ed.). Elsevier.
  5. Cañedo-Dorantes, L., and Cañedo-Ayala, M. (2019). Skin Acute Wound Healing: A Comprehensive Review. International Journal of Inflammation, 2019. https://doi.org/10.1155/2019/3706315
  6. Choi, J., Park, Y. G., Yun, M. S., and Seol, J. W. (2018). Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process. Biomedicine & Pharmacotherapy, 106, 326–332. https://doi.org/10.1016/J.BIOPHA.2018.06.141
  7. Damayanti, N., Prasetyo, A. P., Fadillah, N., Safitri, A., Perdana, R., Setiawan, E., and Ujilestari, T. (2020). Analisis Lendir Bekicot Sebagai Obat Alternatif Bagi Manusia. NECTAR: JURNAL PENDIDIKAN BIOLOGI, 1(2), 9–13.
  8. Deng, T., Gao, D., Song, X., Zhou, Z., Zhou, L., Tao, M., Jiang, Z., Yang, L., Luo, L., Zhou, A., Hu, L., Qin, H., and Wu, M. (2023). A natural biological adhesive from snail mucus for wound repair. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-35907-4
  9. Dewi, P. S., and DS, S. (2020). Lendir Bekicot Meningkatkan Jumlah Sel Makrofag pada Penyembuhan Luka Pasca Pencabutan Gigi Marmut. Interdent.Jkg., 16(1).
  10. El Zawawy, N. A., El-Shenody, R. A., Ali, S. S., and El-Shetehy, M. (2020). A novel study on the inhibitory effect of marine macroalgal extracts on hyphal growth and biofilm formation of candidemia isolates. Scientific Reports, 10(1), 9339. https://doi.org/10.1038/s41598-020-66000-1
  11. EL-Zawawy, N. A., and Mona, M. M. (2021). Antimicrobial efficacy of Egyptian Eremina desertorum and Helix aspersa snail mucus with a novel approach to their anti-inflammatory and wound healing potencies. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-03664-3
  12. Gmur, M. K., and Karpi?ski, T. M. (2020). Povidone-iodine in wound healing and prevention of wound infections. European Journal of Biological Research, 10(3), 232–239. https://doi.org/10.5281/zenodo.3958220
  13. Gonzalez, A. C. D. O., Andrade, Z. D. A., Costa, T. F., and Medrado, A. R. A. P. (2016). Wound healing - A literature review. Anais Brasileiros de Dermatologia, 91(5), 614–620. https://doi.org/10.1590/abd1806-4841.20164741
  14. Gugliandolo, E., Cordaro, M., Fusco, R., Peritore, A. F., Siracusa, R., Genovese, T., D’Amico, R., Impellizzeri, D., Di Paola, R., Cuzzocrea, S., and Crupi, R. (2021). Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice. Scientific Reports, 11(1), 3638. https://doi.org/10.1038/s41598-021-83170-8
  15. Gugliandolo, E., Macrì, F., Fusco, R., Siracusa, R., D’amico, R., Cordaro, M., Peritore, A. F., Impellizzeri, D., Genovese, T., Cuzzocrea, S., Di Paola, R., Licata, P., and Crupi, R. (2021). The protective effect of snail secretion filtrate in an experimental model of excisional wounds in mice. Veterinary Sciences, 8(8). https://doi.org/10.3390/vetsci8080167
  16. Harti, A. S., Sulisetyawati, S. D., Murharyati, A., Oktariani, M., and Wijayanti, I. B. (2016). The Effectiveness of Snail Slime and Chitosan in Wound Healing. International Journal of Pharma Medicine and Biological Sciences. https://doi.org/10.18178/ijpmbs.5.1.76-80
  17. Ilodigwe, E., Ndunagu, L., Ajaghaku, D., and Utoh-Nedosa, U. (2012). Evaluation of the Wound Healing Activity of a Polyherbal Remedy. Annals of Biological Research, 3(11), 5393–5398. www.scholarsresearchlibrary.com
  18. Jeong, J., Toida, T., Muneta, Y., Kosiishi, I., Imanari, T., Linhardt, R. J., Choi, H. S., Wu, S. J., and Kim, Y. S. (2001). Localization and characterization of acharan sulfate in the body of the giant African snail Achatina fulica. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 130(4), 513–519. https://doi.org/10.1016/S1096-4959(01)00468-7
  19. Kermedchiev, M., Lazarova, M., Tancheva, L., Uzunova, D., Tasheva, K., Velkova, L., Dolashki, A., Daskalova, A., Atanasov, V., Kaynarov, D., and Dolashka, P. (2021). Natural substances with therapeutic potential in wound healing. Bulgarian Chemical Communications, 53, 2021. https://doi.org/10.34049/bcc.53.?.0015
  20. Kesumaningrum, W., and Indriyanti, R. A. (2021). Perbandingan Efek Getah Tanaman Jarak Pagar (Jatropha Curcas L) dengan Lendir Bekicot (Achantina Fulica) terhadap Lama Penyembuhan Luka pada Mencit Jantan Galur Swiss Webster. Jurnal Riset Kedokteran, 1(1), 32–37. https://doi.org/10.29313/jrk.v1i1.314
  21. Khan, M. A. O., Ramadugu, R., Suvvari, T. K., M, V., and Thomas, V. (2023). Irritant contact dermatitis due to povidone-iodine following a surgical intervention: An unusual case report. SAGE Open Medical Case Reports, 11, 1–3. https://doi.org/10.1177/2050313X231185620
  22. Landén, N. X., Li, D., and Ståhle, M. (2016). Transition from inflammation to proliferation: a critical step during wound healing. Cellular and Molecular Life Sciences, 73(20), 3861–3885. https://doi.org/10.1007/s00018-016-2268-0
  23. Langdon, J., Patel, M., Ord, R., and Brennan, P. (2011). Operative Oral and Maxillofacial Surgery (2nd ed.). Hodder Arnold.
  24. Mardiyantoro, F. (2018). Penyembuhan Luka Rongga Mulut. UB Press.
  25. McDermott, M., Cerullo, A. R., Parziale, J., Achrak, E., Sultana, S., Ferd, J., Samad, S., Deng, W., Braunschweig, A. B., and Holford, M. (2021). Advancing Discovery of Snail Mucins Function and Application. In Frontiers in Bioengineering and Biotechnology (Vol. 9). Frontiers Media S.A. https://doi.org/10.3389/fbioe.2021.734023
  26. Miloro, M., Ghali, G. E., Larsen, P. E., and Waite, P. D. (2011). Peterson’s Principles of Oral and Maxillofacial Surgery (3rd ed.). People’s Medical Publishing House.
  27. Moore, U. J. (2011). Principles of Oral and Maxillofacial Surgery (6th ed.). Wiley-Blackwell.
  28. Mulholland, B., Tuft, S. J., and Khaw, P. T. (2005). Matrix metalloproteinase distribution during early corneal wound healing. Eye, 19(5), 584–588. https://doi.org/10.1038/sj.eye.6701557
  29. Olczyk, P., Mencner, ?., and Komosinska-Vassev, K. (2015). Diverse Roles of Heparan Sulfate and Heparin in Wound Repair. BioMed Research International, 2015, 1–7. https://doi.org/10.1155/2015/549417
  30. Oroh, C. G., Pangemanan, D. H. C., and Mintjelungan, C. N. (2015). Efektivitas Lendir Bekicot (Achatina fulica) Terhadap Jumlah Sel Fibroblas pada Luka Pasca Pencabutan Gigi Tikus Wistar. Jurnal E-Gigi (EG), 3(2), 515–520.
  31. Pitt, S. J., Graham, M. A., Dedi, C. G., Taylor-Harris, P. M., and Gunn, A. (2015). Antimicrobial properties of mucus from the brown garden snail Helix aspersa. British Journal of Biomedical Science, 72(4), 174–181. https://doi.org/10.1080/09674845.2015.11665749
  32. Primadina, N., Basori, A., and Perdanakusuma, D. S. (2019). Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler. Qanun Medika, 3(1), 31–43.
  33. Purnasari, P. W., Fatmawati, D., and Yusuf, I. (2012). Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus). Sains Medika?: Jurnal Kedokteran Dan Kesehatan, 4(2), 195. https://doi.org/10.30659/sainsmed.v4i2.376
  34. Putra, M. A. (2015). Efektivitas Pemberian Lendir Bekicot 100% (Achatina fulica) dan Sediaan Krim 5% Terhadap Lama Penyembuhan Luka Bakar Derajat II (A) Secara In Vivo. Sekolah Tinggi Ilmu Kesehatan Kusuma Husada Surakarta.
  35. Putri, S. A., and Ismardianita, E. (2016). The effect of ethanol extract of sarang semut plant (Hypnophytum formicarum) to angiogenesis for wound healing after teeth extraction experimental research on marmot (Cavia cobaya). Padjadjaran Journal of Dentistry, 28(3), 177–182.
  36. Ricci, A., Gallorini, M., Feghali, N., Sampò, S., Cataldi, A., and Zara, S. (2023). Snail Slime Extracted by a Cruelty Free Method Preserves Viability and Controls Inflammation Occurrence: A Focus on Fibroblasts. Molecules, 28(3). https://doi.org/10.3390/molecules28031222
  37. Riyani, N. J., Pasaribu, R., and Mardiyantoro, F. (2021). Evaluasi Jumlah Limfosit Pasca Aplikasi Lendir Bekicot (Achatina fulica) Pada Soket Tikus Wistar (Rattus norvegicus). Sinnun Maxillofacial Journal, 3(1), 42–49.
  38. Rosanto, Y. B., Hasan, C. Y., LNU, R., and Surya, A. (2022). The Potential of Snail (Achatina Fulica) Mucus Gel as a Phythopharmaca to Accelerate the Inflammation Process during Wound Healing. World Journal of Dentistry, 13(3), 224–227. https://doi.org/10.5005/jp-journals-10015-2056
  39. Rosanto, Y. B., Hasan, C. Y., Rahardjo, R., and Pangestiningsih, T. W. (2021). Effect of snail mucus on angiogenesis during wound healing. F1000Research, 10, 181. https://doi.org/10.12688/f1000research.51297.1
  40. Santana, W. A., Melo, C. M. de, Cardoso, J. C., Pereira-Filho, R. N., Rabelo, A. S., Reis, F. P., and Albuquerque-Júnior, R. L. C. de. (2012). Assessment of Antimicrobial Activity and Healing Potential of Mucous Secretion of Achatina fulica. International Journal of Morphology, 30(2), 365–373. https://doi.org/10.4067/S0717-95022012000200001
  41. Shoviantari, F., Fajriyah, S., Agustin, E., and Khairani, S. (2021). Uji Aktivitas Gel Lendir Bekicot (Achatina fulica) Sebagai Penyembuhan Luka Sayat. As-Syifaa Jurnal Farmasi, 13(1), 12–19.
  42. Song, Y., Cui, Y., Hao, L., Zhu, J., Yi, J., Kang, Q., Huang, J., and Lu, J. (2021). Wound-healing activity of glycoproteins from white jade snail (Achatina fulica) on experimentally burned mice. International Journal of Biological Macromolecules, 175, 313–321. https://doi.org/10.1016/j.ijbiomac.2021.01.193
  43. Suarni, E., and Badri, P. R. A. (2016). Uji Efektifitas Lendir Bekicot (Achatina Fulica) Dibandingkan dengan Povidon Iodine 10% terhadap Penyembuhan Luka Sayat (Vulnus Scissum) pada Mencit (Mus musculus). Syifa’MEDIKA, 7(1), 9–15.
  44. Trapella, C., Rizzo, R., Gallo, S., Alogna, A., Bortolotti, D., Casciano, F., Zauli, G., Secchiero, P., and Voltan, R. (2018). HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-35816-3
  45. Usman, A. R., and Salikunna, N. A. (2015). Pengaruh Lendir Bekicot (Achatina fulica) terhadap Waktu Penutupan Luka Sayat (Vulnus scissum) pada Mencit (Mus musculus). MEDIKA TADAKULO, 2(1), 31–39.
  46. Vassilev, N. G., Simova, S. D., Dangalov, M., Velkova, L., Atanasov, V., Dolashki, A., and Dolashka, P. (2020). An 1H NMR- and MS-Based Study of Metabolites Profiling of Garden Snail Helix aspersa Mucus. Metabolites, 10(9), 360. https://doi.org/10.3390/metabo10090360
  47. Velnar, T., Bailey, T., and Smrkolj, V. (2009). The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms. Journal of International Medical Research, 37(5), 1528–1542. https://doi.org/10.1177/147323000903700531
  48. Vieira, T. C. R. G., Costa-Filho, A., Salgado, N. C., Allodi, S., Valente, A.-P., Nasciutti, L. E., and Silva, L.-C. F. (2004). Acharan sulfate, the new glycosaminoglycan from Achatina fulica Bowdich 1822. European Journal of Biochemistry, 271(4), 845–854. https://doi.org/10.1111/j.1432-1033.2004.03989.x
  49. Waluga-Koz?owska, E., Jasik, K., Wcis?o-Dziadecka, D., Przemys?aw, P. O. L., Ku?nik-Trocha, K., Komosi?ska-Vassev, K., Olczyk, K., Waluga, M., Olczyk, P., and Zimmermann, A. (2021). Snail Mucus - A Natural Origin Substance with Potential Use in Medicine. Acta Poloniae Pharmaceutica - Drug Research, 78(6), 793–800. https://doi.org/10.32383/appdr/145377
  50. World Health Organization (2013). WHO Traditional Medicine Strategy: 2014-2023. World Health Organization.
  51. Zizioli, D., Mastinu, A., Muscò, A., Bonini, S. A., Finazzi, D., Avisani, R., Kron Morelli, G. B., Pecorelli, S., and Memo, M. (2022). Pro-Angiogenetic Effects of Purified Extracts from Helix aspersa during Zebrafish Development. Current Issues in Molecular Biology, 44(8), 3364–3377. https://doi.org/10.3390/cimb44080232