Potensial Terapi Antikanker Melalui Senyawa Bioaktif dari Nutrasetikal

https://doi.org/10.35912/jimi.v1i2.922
Published: Mar 17, 2022

Abstract:

Purpose: This review aims to examine the current knowledge regarding to the molecular mechanisms by several nutraceuticals, such as retinoids, resveratrol, epigallocatechin 3 gallate, and omega-3 PUFAs to against cancer. Bioactive compounds with high contents in nutraceuticals are considered as complementary components in foods, dietary supplements, and medicines. These compounds can also inhibit carcinogenesis, protect body cells from inflammatory and oxidative processes, and induce anti-proliferative effects in various types of neoplasia.

Research Methodology: The method used is a literature review. The literature search was conducted through Pubmed using keywords in the 2012-2021 timeframe.

Result: The results obtained are that bioactive compounds from nutraceuticals, such as RSV, retinoids, EGCG, and omega-3 PUFAs, have the ability to influence the growth and development of cancer cells, therefore, nutraceuticals can work as innovative anticancer agents.

Limitations: By this method, a thorough literature search may miss important studies that influence conclusions.

Contribution: This research can be applied by all of cancer patients because nutraceutical ingredients are easily available throughout the world, including Indonesia.

Keywords:
1. epigallocatechin gallate
2. cancer
3. cell cycle
4. nutraceuticals
5. polyunsaturated omega-3 fatty acids
6. reservastrol
7. retinoids
Authors:
Winda Puspita sari
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How to Cite
sari, W. P. (2022). Potensial Terapi Antikanker Melalui Senyawa Bioaktif dari Nutrasetikal. Jurnal Ilmu Medis Indonesia, 1(2), 59–70. https://doi.org/10.35912/jimi.v1i2.922
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Vol. 1 No. 2 (2022): Maret
Articles
References

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    Alobaedi, O. H., Talib, W. H., & Basheti, I. A. (2017). Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pacific journal of tropical medicine, 10(4), 400–408. https://doi.org/10.1016/j.apjtm.2017.03.026

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    Augimeri, G., Plastina, P., Gionfriddo, G., Rovito, D., Giordano, C., Fazio, A., Barone, I., Catalano, S., Andò, S., Bonofiglio, D., Meijerink, J., & Witkamp, R. (2019). N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages. Nutrients, 11(9), 2247. https://doi.org/10.3390/nu11092247

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    Ferrucci, L. M., McCorkle, R., Smith, T., Stein, K. D., & Cartmel, B. (2009). Factors related to the use of dietary supplements by cancer survivors. Journal of alternative and complementary medicine (New York, N.Y.), 15(6), 673–680. https://doi.org/10.1089/acm.2008.0387

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    Husna, A. S. (2021). Penatalaksanaan Holistik Scabies pada Anak Usia 4 Tahun di Puskesmas Panjang melalui Pendekatan Kedokteran Keluarga. Jurnal Ilmu Medis Indonesia, 1(1), 25-38. https://doi.org/10.35912/jimi.v1i1.533

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  1. Akhtar, N., & Haqqi, T. M. (2011). Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes. Arthritis Research & Therapy, 13(3), R93. Https://Doi.Org/10.1186/Ar3368
  2. Alobaedi, O. H., Talib, W. H., & Basheti, I. A. (2017). Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer. Asian Pacific journal of tropical medicine, 10(4), 400–408. https://doi.org/10.1016/j.apjtm.2017.03.026
  3. Aquila, S., Santoro, M., Caputo, A., Panno, M. L., Pezzi, V., & De Amicis, F. (2020). The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment. Cells, 9(7), 1725. https://doi.org/10.3390/cells9071725
  4. Aslan, C., Maralbashi, S., Kahroba, H., Asadi, M., Soltani-Zangbar, M. S., Javadian, M., Shanehbandi, D., Baradaran, B., Darabi, M., & Kazemi, T. (2020). Docosahexaenoic acid (DHA) inhibits pro-angiogenic effects of breast cancer cells via down-regulating cellular and exosomal expression of angiogenic genes and microRNAs. Life Sciences, 258, 118094. https://doi.org/10.1016/j.lfs.2020.118094.
  5. Augimeri, G., & Bonofiglio, D. (2021). PPARgamma: A Potential Intrinsic and Extrinsic Molecular Target for Breast Cancer Therapy. Biomedicines, 9(5), 543. https://doi.org/10.3390/biomedicines9050543
  6. Augimeri, G., Plastina, P., Gionfriddo, G., Rovito, D., Giordano, C., Fazio, A., Barone, I., Catalano, S., Andò, S., Bonofiglio, D., Meijerink, J., & Witkamp, R. (2019). N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages. Nutrients, 11(9), 2247. https://doi.org/10.3390/nu11092247
  7. Benvenga, S., Feldt-Rasmussen, U., Bonofiglio, D., & Asamoah, E. (2019). Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition. Nutrients, 11(9), 2214. https://doi.org/10.3390/nu11092214
  8. Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020). The clearance of dead cells by efferocytosis. Nature Reviews. Molecular Cell Biology, 21(7), 398–414. https://doi.org/10.1038/s41580-020-0232-1
  9. D'Eliseo, D., & Velotti, F. (2016). Omega-3 Fatty Acids and Cancer Cell Cytotoxicity: Implications for Multi-Targeted Cancer Therapy. Journal of Clinical Medicine, 5(2), 15. https://doi.org/10.3390/jcm5020015
  10. De Amicis, F., Chimento, A., Montalto, F. I., Casaburi, I., Sirianni, R., & Pezzi, V. (2019). Steroid Receptor Signallings as Targets for Resveratrol Actions in Breast and Prostate Cancer. International Journal of Molecular Sciences, 20(5), 1087. https://doi.org/10.3390/ijms20051087
  11. De Amicis, F., Russo, A., Avena, P., Santoro, M., Vivacqua, A., Bonofiglio, D., Mauro, L., Aquila, S., Tramontano, D., Fuqua, S. A., & Andò, S. (2013). In vitro mechanism for downregulation of ER-? expression by epigallocatechin gallate in ER+/PR+ human breast cancer cells. Molecular Nutrition & Food Research, 57(5), 840–853. https://doi.org/10.1002/mnfr.201200560
  12. Ferraz da Costa, D. C., Campos, N., Santos, R. A., Guedes-da-Silva, F. H., Martins-Dinis, M., Zanphorlin, L., Ramos, C., Rangel, L. P., & Silva, J. L. (2018). Resveratrol prevents p53 aggregation in vitro and in breast cancer cells. Oncotarget, 9(49), 29112–29122. https://doi.org/10.18632/oncotarget.25631
  13. Ferrucci, L. M., McCorkle, R., Smith, T., Stein, K. D., & Cartmel, B. (2009). Factors related to the use of dietary supplements by cancer survivors. Journal of alternative and complementary medicine (New York, N.Y.), 15(6), 673–680. https://doi.org/10.1089/acm.2008.0387
  14. Garg, N., Baishnab, S., Das, R., Kaur, K., Gupta, S., & Arora, S. (2019). Insights of Breast Cancer and Barriers to its Therapy. Journal of Pharmaceutical Technology, Research and Management, 7(2), 73–86. https://doi.org/10.15415/jptrm.2019.72010
  15. Gloria, N. F., Soares, N., Brand, C., Oliveira, F. L., Borojevic, R., & Teodoro, A. J. (2014). Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Research, 34(3), 1377–1386.
  16. Han, G., Xia, J., Gao, J., Inagaki, Y., Tang, W., & Kokudo, N. (2015). Anti-tumor effects and cellular mechanisms of resveratrol. Drug Discoveries & Therapeutics, 9(1), 1–12. https://doi.org/10.5582/ddt.2015.01007
  17. Husna, A. S. (2021). Penatalaksanaan Holistik Scabies pada Anak Usia 4 Tahun di Puskesmas Panjang melalui Pendekatan Kedokteran Keluarga. Jurnal Ilmu Medis Indonesia, 1(1), 25-38. https://doi.org/10.35912/jimi.v1i1.533
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  19. Jin, P., Li, M., Xu, G., Zhang, K., Zheng, L. I., & Zhao, J. (2015). Role of (-)-epigallocatechin-3-gallate in the osteogenic differentiation of human bone marrow mesenchymal stem cells: An enhancer or an inducer?. Experimental and Therapeutic Medicine, 10(2), 828–834. https://doi.org/10.3892/etm.2015.2579
  20. Kemenkes RI. (2015). Buletin Kanker: Situasi Penyakit Kanker. Pusat Data dan Informasi Kemenkes RI.
  21. Kim, H. S., Quon, M. J., & Kim, J. A. (2014). New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate. Redox biology, 2, 187–195. https://doi.org/10.1016/j.redox.2013.12.022
  22. Kunnumakkara, A. B., Sailo, B. L., Banik, K., Harsha, C., Prasad, S., Gupta, S. C., Bharti, A. C., & Aggarwal, B. B. (2018). Chronic diseases, inflammation, and spices: how are they linked?. Journal of Translational Medicine, 16(1), 14. https://doi.org/10.1186/s12967-018-1381-2
  23. Li, Y., Li, S., Meng, X., Gan, R. Y., Zhang, J. J., & Li, H. B. (2017). Dietary Natural Products for Prevention and Treatment of Breast Cancer. Nutrients, 9(7), 728. https://doi.org/10.3390/nu9070728
  24. Lin, G., Zhu, S., Wu, Y., Song, C., Wang, W., Zhang, Y., Chen, Y. L., & He, Z. (2017). ?-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines. Scientific reports, 7(1), 2929. https://doi.org/10.1038/s41598-017-03231-9
  25. Moradzadeh, M., Hosseini, A., Erfanian, S., & Rezaei, H. (2017). Epigallocatechin-3-gallate promotes apoptosis in human breast cancer T47D cells through down-regulation of PI3K/AKT and Telomerase. Pharmacological reports : PR, 69(5), 924–928. https://doi.org/10.1016/j.pharep.2017.04.008
  26. M., et al. (2017). Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging, 9(6), 1477–1536. https://doi.org/10.18632/aging.101250
  27. Munyawarara, N., & Govender, K. K. (2020). Clustering the agricultural SME sector in Eastern Highlands, Zimbabwe. International Journal of Financial, Accounting, and Management, 1(4), 247-255. https://doi.org/10.35912/ijfam.v1i4.139
  28. Nasri, H., Baradaran, A., Shirzad, H., & Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International journal of preventive medicine, 5(12), 1487–1499.
  29. Nivya, A., Kaliyappan, R., Vel, K., Sasidharan, S., & GS, S. (2012). Role of Nutraceuticals in Cancer. International Journal of Pharmacy and Pharmaceutical Sciences, 4, 415-420.
  30. Perdani, A. P., & Berawi, K. N. (2021). Manajemen Holistik dengan Pendekatan Kedokteran Keluarga pada Pasien Wanita 37 Tahun dengan Hipertensi Primer. Jurnal Ilmu Medis Indonesia, 1(1), 17-24. https://doi.org/10.35912/jimi.v1i1.505
  31. Pfeffer, C. M., & Singh, A. (2018). Apoptosis: A Target for Anticancer Therapy. International journal of molecular sciences, 19(2), 448. https://doi.org/10.3390/ijms19020448
  32. Reinhardt, A., Liu, H., Ma, Y., Zhou, Y., Zang, C., Habbel, J. P., Possinger, K., & Eucker, J. (2018). Tumor Cell-selective Synergism of TRAIL- and ATRA-induced Cytotoxicity in Breast Cancer Cells. Anticancer research, 38(5), 2669–2682. https://doi.org/10.21873/anticanres.12509
  33. Rovito, D., Gionfriddo, G., Barone, I., Giordano, C., Grande, F., De Amicis, F., Lanzino, M., Catalano, S., Andò, S., & Bonofiglio, D. (2016). Ligand-activated PPAR? downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression. Oncotarget, 7(40), 65109–65124. https://doi.org/10.18632/oncotarget.11371
  34. Rovito, D., Giordano, C., Plastina, P., Barone, I., De Amicis, F., Mauro, L., Rizza, P., Lanzino, M., Catalano, S., Bonofiglio, D., & Andò, S. (2015). Omega-3 DHA- and EPA-dopamine conjugates induce PPAR?-dependent breast cancer cell death through autophagy and apoptosis. Biochimica et biophysica acta, 1850(11), 2185–2195. https://doi.org/10.1016/j.bbagen.2015.08.004
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