Peran Kadar Vitamin D Darah terhadap Derajat Keparahan Klinis Pasien Bell’s Palsy

https://doi.org/10.35912/jimi.v3i1.1470
Published: Sep 8, 2023

Abstract:

Purpose: This study aims to determine the effect of blood vitamin D levels on clinical severity in patients with Bell's palsy.

Methodology/approach: The study was conducted with longitudinal observational analytic on patients with Bell’s palsy. Vitamin D levels in the form of 25-hydroxyvitamin D (25(OH)D were measured in each subject. The clinical severity was evaluated using the House-Brackmann grading.

Results/findings: A total of 20 patients (10 women, 10 men, mean age 48.8 ± 12, 97 years, range 22-72 years) were evaluated between March-July 2022. Vitamin D deficiency was present in 13 (65%) patients, insufficiency in 7 (35%) patients, and no normal blood vitamin D levels were found in patients with Bell’s palsy. Two (10%) patients with grade 3 Bell’s palsy, six (30%) grade 4 patients, and twelve (60%) grade 5 patients. Results showed higher clinical severity had lower vitamin D levels. Statistical analysis showed a significant difference with p value = 0.003.

Limitations: The research that discusses the dosage, method, and duration of vitamin D administration in patients with Bell's palsy still very limited.

Contribution: With further research, it can be proven vitamin D deficiency can be associated with Bell's palsy, so appropriate treatment and prevention can be given.

Keywords:
1. Bell’s palsy
2. Vitamin D
3. Clinical Severity
Authors:
1 . Mutia Sinta
2 . Sulistyani Sulistyani
3 . Yuhanida Ratnasari
https://orcid.org/0000-0002-1825-0097
4 . Fitri Pranita Milyarona
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How to Cite
Sinta, M. ., Sulistyani, S. ., Ratnasari, Y. ., & Milyarona, F. P. (2023). Peran Kadar Vitamin D Darah terhadap Derajat Keparahan Klinis Pasien Bell’s Palsy . Jurnal Ilmu Medis Indonesia, 3(1), 1–8. https://doi.org/10.35912/jimi.v3i1.1470
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Vol. 3 No. 1 (2023): September
Articles
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    AlJohri, R., AlOkail, M., & Haq, S. H. (2019). Neuroprotective role of vitamin D in primary neuronal cortical culture. eNeurologicalSci, 14, 43-48.

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    He, R., Hu, Y., Zeng, H., Zhao, J., Zhao, J., Chai, Y., . . . Jia, W. (2017). Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Metab Res Rev, 33(2), 1-9. doi:10.1002/dmrr.2820

    Husna, A. S. (2021). Penatalaksanaan Holistik Scabies pada Anak Usia 4 Tahun di Puskesmas Pajang Melalui Pendekatan Kedokteran Keluarga (Holistic Management of Scabies in 4 Year-Old-Child at Puskesmas Panjang with Family Doctor Approach). Jurnal Ilmu Medis Indonesia (JIMI), 1(1), 25-38.

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    Ocak, E., Uyar, M. S., Kocaoz, D., Mirici, E., & Acar, A. (2020). Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates, 10(3), 439-443. doi:10.32448.entupdates.814569

    Oraby, M., Srie, M. A., Abdelshafy, S., & Elfar, E. (2019). Diabetic peripheral neuropathy: the potential role of vitamin D deficiency. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 22(10), 1-5.

    PERDOSSI. (2016). Panduan Praktik Klinis. Jakarta: Perhimpunan Dokter Spesialis Saraf.

    Priya, R., Monga, S., & Malik, J. (2019). Bell’s palsy: Our experience and review of 30 cases. Otorhinolaryngology-Head and Neck Surgery, 4(2), 1-3. doi:doi: 10.15761/ohns.1000202.

    Somasundara, D., Sullivan, F., & Cheesbrough, G. (2017). Management of Bell's palsy Aetiolgy. Journal of Australia, 40(3), 1-9.

    Somma, C. D., Scarano, E., Barrea, L., Zhukouskaya, V. V., Savastano, S., Mele, C., . . . Marzullo, a. P. (2017). Vitamin D and Neurological Diseases: An Endocrine View. International Journal of Molecular Sciences, 18(11), 2482. doi:https://doi.org/10.3390%2Fijms18112482

    Swain, S., Agrawala, R., & Pani, S. (2021). Bell's Palsy and Its Social Impact: Our Experiences at a Tertiary Care Teaching Hospital of Eastern India. International Journal of Current Research and Review, 13(10), 80-84.

    Yusefa, M., Wijayanto, W. P., Sutrisno, S., & Suwantoro, D. (2023). Hubungan Nyeri Rheumatoid Arthritis dengan Kemandirian ADL pada Lansia (Correlation Between Rheumatoid Arthritic Pain With Independence Activity Of Daily Livingon The Elderly). Journal Ilmu Medis Indonesia (JIMI), 2(2), 61-67.

    Zhang, W., Xu, L., Luo, T., Wu, F., & Zhao, B. (2020). The etiology of Bell’s palsy: a review. Journal of Neurology, 267(7), 1896-1905.

  1. Adam, O. M. (2019). Bell’s palsy. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 8(1), 137-149.
  2. AlJohri, R., AlOkail, M., & Haq, S. H. (2019). Neuroprotective role of vitamin D in primary neuronal cortical culture. eNeurologicalSci, 14, 43-48.
  3. Angela, K. A., & Sutarka, I. N. (2021). PERAN EFEK IMUNOMODULASI VITAMIN D PERAN EFEK IMUNOMODULASI VITAMIN D . Jurnal Kedokteran Unram, 10(2), 927-933.
  4. Bahrudin, M. (2011). Bell’s Palsy (BP). Bell’s Palsy (BP), 7(15), 20-25.
  5. Berawi, K. N., & Nugroho, I. (2021). Efek Neuroprotektif Kafein terhadap Fungsi Motorik pada Penyakit Parkinson (Neuroprotective Effects of Caffeine on Motor Function in Parkinson's Disease). Jurnal Ilmu Medis Indonesia (JIMI), 1(1), 13-15.
  6. Eviston, T., Croxson, G., & Kennedy, P. (2015). Bell’s palsy: Aetiology, clinical features and multidisciplinary care. Journal of Neurology, Neurosurgery and Psychiatry, 1356-1361. doi: doi: 10.1136/jnnp-2014-309563
  7. Fujiwara, T., Namekawa, M., Kuriyama, A., & Tamaki, H. (2019). High-dose Corticosteroids for Adult Bell's Palsy: Systematic Review and Meta-analysis. Otology & Neurotology Journal, 40(8), 1101-1108. doi:doi.org/10.1097/MAO.0000000000002317
  8. Gagyor, I., Madhok, V. B., Daly, F., & Sullivan, F. (2019). Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database of Systematic Reviews, 9(9), 1-68. doi:doi.org/10.1002/14651858.cd001869.pub9
  9. Göker, A. E., Karaketir, S., Alagöz, M. H., Alagöz, M. H., Alagöz, M. H., Alagöz, M. H., & Ba?aran, N. (2020). The effect of vitamin D levels on prognosis of patients with facial paralysis. Behbut Cevan?ir Otorhinolaryngology-Head and Neck Surgery Society, 30(4), 118-122. doi:doi.org/10.5606/Tr-ENT.2020.88942
  10. He, R., Hu, Y., Zeng, H., Zhao, J., Zhao, J., Chai, Y., . . . Jia, W. (2017). Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes. Diabetes Metab Res Rev, 33(2), 1-9. doi:10.1002/dmrr.2820
  11. Husna, A. S. (2021). Penatalaksanaan Holistik Scabies pada Anak Usia 4 Tahun di Puskesmas Pajang Melalui Pendekatan Kedokteran Keluarga (Holistic Management of Scabies in 4 Year-Old-Child at Puskesmas Panjang with Family Doctor Approach). Jurnal Ilmu Medis Indonesia (JIMI), 1(1), 25-38.
  12. Kang, H. M., Jung, S. Y., Byun, J. Y., Park, M. S., & Yeo, S. G. (2015). Steroid plus antiviral treatment for Bell's palsy. Journal of Internal Medicine, 277(1), 532-539. doi:doi: 10.1111/joim.12288
  13. Kim, S., & Lee, H. Y. (2020). Acute Peripheral Facial Pasy: Recent Guidelines and a Systematic Review of the Literature. Journal of Korean Medical Science, 35(30). doi:doi.org/10.3346/jkms.2020.35.e245
  14. Kumar, K. H., Shijith, K., & Ahmad, F. (2016). Bells's palsy at high altitude- an unsuspected finding. Military Medical Research, 3(18), 1-3.
  15. Kurniawan, S. N. (2012). Buku Ajar Saraf Perifer (Cetakan Pertama ed.). Malang: UB Press.
  16. Montava, M., Garcia, S., Mancini, J., Jammes, Y., Courageot, J., Lavieille, J.-P., & Feron, F. (2014). Vitamin D3 potentiates myelination and recovery after facial nerve injury. Eur Arch Otorhinolaryngol, 272(10), 1815-2823. doi:doi/10.1007/s00405-014-3305-y
  17. Mubina, J. F., & Wahyuni, A. (2021). Pengaruh Vitamin D terhadap Keparahan dan Mortalitas COVID-19. Medula Jurnal, 11(1), 184-189.
  18. Nurfaizah, F. Z. (2021). Miastenia Gravis Okular Juvenil: Laporan Kasus (Juvenile Ocular Myasthenia Gravis: A Case Report). Jurnal Ilmu Medis Indonesia (JIMI), 1(1), 39-52.
  19. Ocak, E., Uyar, M. S., Kocaoz, D., Mirici, E., & Acar, A. (2020). Role of Vitamin D Deficiency on The Onset and Prognosis of Bell’s Palsy. ENT Updates, 10(3), 439-443. doi:10.32448.entupdates.814569
  20. Oraby, M., Srie, M. A., Abdelshafy, S., & Elfar, E. (2019). Diabetic peripheral neuropathy: the potential role of vitamin D deficiency. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 22(10), 1-5.
  21. PERDOSSI. (2016). Panduan Praktik Klinis. Jakarta: Perhimpunan Dokter Spesialis Saraf.
  22. Priya, R., Monga, S., & Malik, J. (2019). Bell’s palsy: Our experience and review of 30 cases. Otorhinolaryngology-Head and Neck Surgery, 4(2), 1-3. doi:doi: 10.15761/ohns.1000202.
  23. Somasundara, D., Sullivan, F., & Cheesbrough, G. (2017). Management of Bell's palsy Aetiolgy. Journal of Australia, 40(3), 1-9.
  24. Somma, C. D., Scarano, E., Barrea, L., Zhukouskaya, V. V., Savastano, S., Mele, C., . . . Marzullo, a. P. (2017). Vitamin D and Neurological Diseases: An Endocrine View. International Journal of Molecular Sciences, 18(11), 2482. doi:https://doi.org/10.3390%2Fijms18112482
  25. Swain, S., Agrawala, R., & Pani, S. (2021). Bell's Palsy and Its Social Impact: Our Experiences at a Tertiary Care Teaching Hospital of Eastern India. International Journal of Current Research and Review, 13(10), 80-84.
  26. Yusefa, M., Wijayanto, W. P., Sutrisno, S., & Suwantoro, D. (2023). Hubungan Nyeri Rheumatoid Arthritis dengan Kemandirian ADL pada Lansia (Correlation Between Rheumatoid Arthritic Pain With Independence Activity Of Daily Livingon The Elderly). Journal Ilmu Medis Indonesia (JIMI), 2(2), 61-67.
  27. Zhang, W., Xu, L., Luo, T., Wu, F., & Zhao, B. (2020). The etiology of Bell’s palsy: a review. Journal of Neurology, 267(7), 1896-1905.